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РЖ ВИНИТИ 34 (BI23) 95.11-04М2.292

Vornanen, Matti.
Tension-voltage relations of single myocytes reflect Ca release triggered by Na/Ca exchange at 35'ГРАДУС'C but not 23'ГРАДУС'C [Text] / Matti Vornanen, Neal Shepherd, Gerrit Isenberg // Amer. J. Physiol. - 1994. - Vol. 267, N 2. - P623-632 . - ISSN 0002-9513
Перевод заглавия: Связь напряжение-потенциал в одиночном миоците отражает высвобождение Ca, запускаемого Na/Ca обменом при 35'ГРАДУС'C, но не при 23'ГРАДУС'C
Аннотация: Contractile tension in response to 200-ms voltage-clamp pulses was measured in isolated guinea pig ventricular cells conditioned to constant Ca load. At 23'ГРАДУС'C, the tension-voltage relation was bell shaped, decaying from a maximum at +20 mV to zero at +100 mV, but at 35'ГРАДУС'C it was sigmoidal, with similar twitch tensions at +20 and +100 mV. Tension at 35'ГРАДУС'C and +100 mV was reduced by ryanodine or caffeine and abolished by removal of Ca just before the test pulse. At 35'ГРАДУС'C and +100 mV, twitch tension increased markedly as the Na concentration in the patch pipette ([Na][p]) was varied between 0 and 20 mM. Cd (300 'мю'M) blocked tension at all potentials at 23'ГРАДУС'C, but tension remained in the presence of Cd at 35'ГРАДУС'C (29% of control at +2 mV and 100% of control at +100 mV). The results suggest that fast contractions due to sarcoplasmic reticulum Ca release can be triggered by Ca influx through either Ca current (I[Ca]) or Na/Ca exchange and that those triggered through exchage are much more temperature sensitive than those triggered by I[Ca]. США, N. Shepherd, Research Service/151L, Veterans Affairs Med. Center, 508 Fulton St., Durham, NC 27705. Библ. 32

ГРНТИ	34.39.29

ВИНИТИ 341.39.29.11.21.09
Рубрики: СЕРДЦЕ
КАРДИОМИОЦИТЫ
НАПРЯЖЕНИЕ СОКРАЩЕНИЯ
БИОПОТЕНЦИАЛЫ
КАЛЬЦИЙ
ТЕМПЕРАТУРА
МОРСКИЕ СВИНКИ

Доп.точки доступа:
Shepherd, Neal; Isenberg, Gerrit

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