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РЖ ВИНИТИ 34 (BI23) 96.06-04М2.379

Kobayashi, Shigeki.
Изменения в порядке следования систолической нагрузки вызывает различное ремоделирование в гипертрофическом левом желудочке крысы [Text] / Shigeki Kobayashi // Yamaguchi igaku = Yamaguchi Med. J. - 1995. - Vol. 44, N 2. - С. 85-94 . - ISSN 0513-1731
Аннотация: To study the effect of a change in systolic loading sequence on a development of LV hypertrophy due to pressure-overload, early systolic loading was produced by the coarctation of ascending aorta (ASCn-9), and late systolic loading by the coarctation of abdominal aorta (ABD: n=8) in 6-week-old rats. Peak LV pressure increased both in ASC and ABD (ASC:197'+-'10 vs ABD:203'+-'11mmHg, ns). We also measured LV wall thickness (W) and LV internal diameter (D) with sonomicrometry (20 MHz), and W/D ratio was calculated as an index of eccentricity. In ASC, W/D ratio decreased compared with Sham (ASC:0.6'+-'0.1 vs Sham:1.1'+-'0.2, p.05), indicating a development of eccentric LV hypertrophy, whereas no difference of W/D ratio was found between Sham and ABD. Collagen volume fraction (CVF: by image analyzer) in subendocardial region was higher in ABD (6.2'+-'0.6%) than in ASC (5.2'+-'0.5%, p.05) with no significant difference in subepicardial CVF. Myocyte diameter was also larger in ABD (16.1'+-'1.2 'мю'm) than in ASC (14.5'+-'0.6 'мю'm, p.05). The levels of plasma angiotensin II and aldosterone at both 10 days and 4 weeks after surgery were not different among 3 groups. Библ. 20

ГРНТИ	34.39.29

ВИНИТИ 341.39.29.11.99
Рубрики: СЕРДЦЕ
ГИПЕРТРОФИЯ
КОАРКТАЦИЯ ВОСХОДЯЩЕЙ АОРТЫ
КОАРКТАЦИЯ БРЮШНОЙ АОРТЫ
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