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РЖ ВИНИТИ 34 (BI14) 96.03-04Б4.267

Recombinant E. coli-derived tissue factor pathway inhibitor reduces coagulopathic and lethal effects in the baboon gram-negative model of septic shock [Text] / C. Carr [et al.] // Circ. Shock. - 1994. - Vol. 44, N 3. - P126-137 . - ISSN 0092-6213
Перевод заглавия: Рекомбинантный E. coli - производный тканевой фактор-ингибитор метаболизма снижает коагулопатическое и летальное действие грамотрицательного септического шока на модели бабуинов
Аннотация: Excessive coagulation is a typical response to the vascular injury occurring in gram negative sepsis. This study evaluated the pharmacological effects of the use of a recombinant Escherichia coli derived form of tissue factor pathway inhibitor (ala-TFPI) in a baboon model of septic shock. Several doses of ala-TFPI were administered either 30 or 120 min after the initiation of a lethal intravenous infusion of E. coli into baboons. Treatment at 30 min with either 2.7 or 7.4 mg/kg of ala-TFPI resulted in the same survival rates and attenuation of both the coagulation response and cellular injury, as measured by clinical chemistry. When administration of ala-TFPI was delayed for 120 min, a dose of ala-TFPI protein continued to provide a benefit to survival. Ala-TFPI reduced the drop in mean systemic arterial pressure compared to control baboons in addition to partially attenuating the coagulopathic response. Baboons given ala-TFPI also maintained lower levels of plasma interleukin-6 (IL-6) and thrombin-antithrombin. These results suggest that the site of action of the protein may involve the later stage components of the coagulation and inflammatory pathways. Ил. 6. Табл. 4. Библ. 21

ГРНТИ	34.27.29

ВИНИТИ 341.27.29.21.09
Рубрики: ESCHERICHIA COLI (BACT.)
РЕКОМБИНАНТНЫЕ ШТАММЫ
ТКАНЕВОЙ ФАКТОР
ИНГИБИТОР МЕТАБОЛИЗМА
СЕПТИЧЕСКИЙ ШОК
ЖИВОТНЫЕ МОДЕЛИ

Доп.точки доступа:
Carr, C.; Bild, G.S.; Chang, A.C.K.; Peer, G.T.; Palmier, M.O.; Frazier, R.B.; Gustafson, M.E.; Wun, T.-C.; Creasey, A.A.; Hinshaw, L.B.; Taylor, F.B.; Galluppi, G.R.

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