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РЖ ВИНИТИ 34 (BI26) 96.03-04М4.254

Anil, Kesavanhaly.
Effect of feeding sardine oil on synthesis and secretion of apolipoprotein B-containing lipoproteins by rabbit hepatocytes [Text] / Kesavanhaly Anil, Perumana R. Sudhakaran // Nutrition. - 1995. - Vol. 11, N 1. - P17-20 . - ISSN 0899-9007
Перевод заглавия: Влияние потребления жира сардин на синтез и секрецию липопротеина, содержащего апо-B в гепатоцитах кролика
Аннотация: Rabbits were fed a diet containing 10% sardine oil or groundnut oil for 6 wk. A significant decrease in serum cholesterol and triglycerides was observed in rabbits receiving sardine oil. Radiolabeling studies with [{3}H]leucine and [{14}C]acetate on the synthesis and secretion of apolipoprotein B (apoB)-containing lipoproteins by primary cultures of rabbit hepatocytes were carried out. Significantly lower incorporation of [{3}H]leucine into apoB secreted into the medium by hepatocytes derived from rabbits fed sardine oil indicates a reduced synthesis and secretion of apoB-containing lipoproteins. This was further confirmed by a decreased incorporation of [{14}C]acetate into cholesterol and cholesteryl ester associated with lipoprotein floating at the very-low-density lipoprotein density range. Radioactivity incorporated into cholesterol associated with the cell layer was also reduced. These results indicate that sardine oil exerts a hypolipidemic action in rabbits mainly by decreasing the synthesis and secretion of apoB-containing lipoproteins by liver

ГРНТИ	34.39.41

ВИНИТИ 341.39.41.21.15.45
Рубрики: ПИТАНИЕ ЖИРОВОЕ
ЖИР САРДИН
ЛИПОПРОТЕИНЫ
КРОЛИКИ

Доп.точки доступа:
Sudhakaran, Perumana R.

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