СибНСХБ

Вид поиска

Область поиска

Найдено в других БД

Формат представления найденных документов:
библиографическое описание	краткий	полный

Поисковый запрос: (<.>S=ДИГИДРОКСИВИТАМИН D[3] 1,25<.>)

Общее количество найденных документов : 1

РЖ ВИНИТИ 34 (BI26) 95.12-04М4.160

Boland, Ana R. de
1,25(OH)[2]-vitamin D[3] signal transduction in chick myoblasts involves phosphatidylcholine hydrolysis [Text] / Ana R.de Boland, Susana Morelli, Ricardo Boland // J. Biol. Chem. - 1994. - Vol. 269, N 12. - P8675-8679 . - ISSN 0021-9258
Перевод заглавия: Сигнальная трансдукция 1,25-дигидроксивитамина D[3] в миобластах цыпленка вовлечена в гидролиз фосфатидилхолина
Аннотация: 1,25-Dihydroxyvitamin D[3] (1,25(OH)[2]D[3]) rapidly stimulates the biphasic formation of diacylglycerol (DAG) in chick myoblasts. Neomycin (0.5 mм), an inhibitor of phosphoinositide hydrolysis, abolished the first phase (1 min) but had no effect on the second 1,25(OH)[2]D[3]-induced DAG peak (5 min). In myoblasts prelabeled with [{3}H]choline, 1,25(OH)[2]D[3] increased the release of [{3}H]choline (maximally at 5 min), with a concomitant decrease in phosphatidylcholine and the absence of significant changes in phosphocholine. 1,25(OH)[2]D[3] caused a significant increase in phosphatidylethanol (PEt) formation in myoblasts in the presence of 1.5% ethanol. The effects of 1,25(OH)[2]D[3] were time- and dose-dependent (10{-11} to 10{-8} м) and specific as 25OHD[3] and 24,25(OH)[2]D[3] failed to accumulate PEt. 12-O-Tetradecanoylphorbol-13-acetate also stimulated PEt formation. The combination of 1,25 (OH)[2]D[3] and 12-O-tetradecanoylphorbol-13-acetate was more effective than either compound alone. Neither the PKC inhibitor H[7] nor PKC down-regulation blocked the hormone-induced increast in PEt. The effects of 1,25(OH)[2]D[3] were, however, inhibited in the absence of extracellular Ca{2+} (+EGTA) and by nifedipine and verapamil, whereas the Ca{2+} ionophore A23187 also increased PEt generation. Аргентина, Dep. Biol., Univ. Nac. del Sur. San Juan G76, Bahia Blanca 8000. Библ. 39

ГРНТИ	34.39.41

ВИНИТИ 341.39.41.25.17.17
Рубрики: ДИГИДРОКСИВИТАМИН D[3] 1,25
СИГНАЛЬНАЯ ТРАНСДУКЦИЯ
МИОБЛАСТЫ
ВОВЛЕЧЕНИЕ
ФОСФАТИДИЛХОЛИН
ГИДРОЛИЗ
ЦЫПЛЯТА

Доп.точки доступа:
Morelli, Susana; Boland, Ricardo

"Электронные каталоги и базы данных библиотек СО РАН"

© Международная Ассоциация пользователей и разработчиков электронных библиотек и новых информационных технологий
(Ассоциация ЭБНИТ)

rtvarBDview(" результаты поиска","20190607010228","4682442");

Вид поиска