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РЖ ВИНИТИ 34 (BI23) 96.04-04М2.563

Effect of nonpeptide vasopressin receptor antagonists on developing, and established DOSA-salt hypertension in rats [Text] / H. Okada [et al.] // Clin. and Exp. Hypertens. - 1995. - Vol. 17, N 3. - P469-483 . - ISSN 1064-1963
Перевод заглавия: Влияние непептидных антагонистов вазопрессиновых рецепторов на развитие и становление ДОКА-солевой гипертензии у крыс
Аннотация: Twenty-nine Wistar rats were heminephrectomized, and administered DOCA (50 mg/kg; intraperitoneally twice a week) and salt (5% NaCl diet) from week 0 to the end of study. Group 1 rats were served as control. Group 2 and 5 rats were given a V1 antagonist, and groups 3 and 6 rats were given a V2 antagonist, while groups 4 and 7 rats received both V1 and V2 antagonists. Each drug was started to groups 2, 3 and 4 at week 0, and to groups 5, 6 and 7 at week 4. Significant amelioration of the increase in blood pressure was observed in groups 3 and 4 at week 10, and a reduction in blood pressure occurred in groups 6 and 7 at week 10. Otherwise, a V1 antagonist alone slightly attenuated blood pressure rise in the group 2 without significance, and failed to lower blood pressure of the group 5 during the study. These results suggest that both V1 and V2 agonisms are involved in an increase in blood pressure at the developing stage of DOCA-salt hypertension, and that V2 agonism, but not V1 plays a major role in the maintenance of high blood pressure at the established stage. Библ. 28

ГРНТИ	34.39.29

ВИНИТИ 341.39.29.19.17.15
Рубрики: ГИПЕРТЕНЗИЯ
ДЕЗОКСИКОРТИКОСТЕРОНАЦЕТАТ-СОЛЕВАЯ МОДЕЛЬ
АРТЕРИАЛЬНОЕ ДАВЛЕНИЕ
ВАЗОПРЕССИНОВЫЕ РЕЦЕПТОРЫ
КРЫСЫ

Доп.точки доступа:
Okada, H.; Suzuki, H.; Kanno, Y.; Saruta, T.

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