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РЖ ВИНИТИ 34 (BI48) 95.11-04Т2.186

Effect of anti-inflammatory agent etodolac on antigen-induced contractions of the trachea and lung parenchyma of guinea pigs [Text] / K. Inoue [et al.] // Prostagland., Leukotrienes and Essent. Fatty Acids. - 1994. - Vol. 51, N 6. - P451-455 . - ISSN 0952-3278
Перевод заглавия: Влияние противовоспалительного средства этодолака на вызываемые антигеном сокращения трахеи и паренхимы легких морских свинок
Аннотация: Etodolac, which inhibits the activity of cyclooxygenase, did not affect antigen-induced contractions of the trachea and lung parenchyma of guinea pigs. Indomethacin tended to enhance antigen-induced contractions of the trachea and significantly enhanced contractions of the lung parenchyma. The inhibitory activity of AA-861, a 5-lipoxygenase inhibitor, in antigen-induced contractions of the trachea and lung parenchyma was more potent than that of ozagrel, a thromboxane A[2] (TXA[2]) inhibitor. Thus, lipoxygenase products played a more important role than TXA[2] in antigen-induced contractions of the trachea and lung parenchyma. These results suggest that the enhancement of antigen-induced contractions by indomethacin might be due to an increase in anaphylactic release of lipoxygenase products through the inhibition of cyclooxygenase. Since etodolac did not enhance antigen-induced contractions, we attempted to determine whether or not etodolac inhibits 5-lipoxygenase. Etodolac was found to have no effect on 5-lipoxygenase activity. Therefore, the low adverse effect of etodolac on antigen-induced contractions of the airway may be due to its weak inhibition of cyclooxygenase in the airway. These results suggest that etodolac would have only a very slight, if any, adverse effect on the airway in patients with asthma. Япония, Res. Lab., Nippon ShinyaKu. Co, Ltd., Nishiohji-Hachijo, Minami-Ku, Kyoto 601. Библ. 23

ГРНТИ	34.45.21

ВИНИТИ 341.45.21.79
Рубрики: МЫШЕЧНОЕ СОКРАЩЕНИЕ
ВЫЗВАННОЕ АНТИГЕНОМ
ВЛИЯНИЕ ЭТОДОЛАКА
ЛЕГКИЕ
МОРСКИЕ СВИНКИ

Доп.точки доступа:
Inoue, K.; Hamada, K.; Ueda, F.; Shibata, Y.; Kimura, K.

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