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РЖ ВИНИТИ 76 (BI28) 96.02-04Н3.144

Автор(ы) : Kubota, Keiichi, Kajiura, Naoaki, Konishi, Toshiro, Teruya, Masanori, Tsushima, Hidefumi, Nakao, Kentaro, Arizono, Saori, Oka, Teruaki, Mauuchi, Masatoshi
Заглавие : Effects of preoperative chamotherapy on DNA ploidy patterns, cell cycle, and histological findings in gastric and colonic cancer patients
Источник статьи : J. Surg. Oncol. - 1994. - Vol. 57, N 4. - С. 222-229
Аннотация: Thirty-nine patients with gastric or colonic cancer were given preoperative chemotherapy with UFT (an admixture of tegafur and uracil). Biopsy specimens for analysis were obtained before chemotherapy through a gastroscope or colonoscope and after chemotherapy from resected tumors. The DNA ploidy patterns and cell cycles were evaluated using a flow cytometer and the tissues were examined histologically. The DNA ploidy pattern was diploid (D) in 12 gastric and 13 colonic cancer patients and aneuploid (A) in 10 and 4 patients, respectively. After chemotherapy, the pattern changed in nine gastric (A'-'D: 7, D'-'A: 2) and six colonic cancer patients (A'-'D: 3, D'-'A: 3) and was unchanged in the remaining patients. Cell cycle analysis showed decreased Gl- and increased S-phase fractions in 10 of 12 patients with gastric and 6 of 10 patients with colonic cancer. Histilogically, decreased tumor cellularity, increased fibrosis, and/or cytological changes were observed in both cancers after chemotherapy. Gastric and colonic cancers in which the DNA ploidy pattern changed from aneuploid to diploid, Gl- decreased and S-phase increased, and/or histological changes were observed, were considered to have responded to preoperative UFT administration. Библ. 31
ГРНТИ : 76.29.49
Предметные рубрики: РАК ЖЕЛУДКА
ПЛОИДНОСТЬ
ГИСТОЛОГИЯ
РАК ТОЛСТОЙ КИШКИ
ХИМИОТЕРАПИЯ
ТЕГАРУР
UFT
ЧЕЛОВЕК
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