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Вид документа : Статья из журнала

РЖ ВИНИТИ 34 (BI23) 95.11-04М2.166

Автор(ы) : Klocking H.-P.
Заглавие : Acute t-PA releasing effect of supersulphated low molecular weight heparins
Источник статьи : Fibrinolysis. - 1994. - Vol. 8, Suppl. n 1. - С. 75-77
Аннотация: Different supersulphated low molecular weight heparins (SSLMWH), isolated after controlled depolymerisation and contemporary sulphatation of pig mucosal unfractionated heparin (Italian Patent 22504 A/89), were tested for their in vitro and in vivo t-PA releasing activity. The different SSH preparations developed profibrinolytic activity on the basis of tissue-type plasminogen activator (t-PA) release during perfusion of isolated pig ear and after i. v.-application in rats. The acute t-PA release induced by SSH 11, 13 and 14 was in a higher range in the isolated perfused pig ear model than that induced by unfractionated heparin at a concentration of 50 mg/ml perfusion solution. The highest acute increase of t-PA was caused by SSH 14 with 200%. SSH 14 was dose-dependently tested for acute t-PA release in rats after intravenous administration of 1.0, 2.5, 5.0 and 10.0 mg SSH/kg body weight. The maximum net increase of t-PA release was reached 1 to 5 min after i. v. application of SSH 14. After the administration of 5 or 10 mg/kg, resp., SSH 14 produced an increase in maximum t-PA release between 7 and 8 I. U./ml plasma. The t-PA releasing effect of SSLMWH might contribute to the antithrombotic effect of SSH 14. Библ. 10
ГРНТИ : 34.39.27
Предметные рубрики: ГЕПАРИНЫ НИЗКОМОЛЕКУЛЯРНЫЕ
СУПЕРСУЛЬФАТИРОВАННЫЕ
ТКАНЕВОЙ АКТИВАТОР ПЛАЗМИНОГЕНА
ВЫСВОБОЖДЕНИЕ
КРЫСЫ
СВИНЬИ
ФИБРИНОЛИЗ
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Вид документа : Статья из журнала

РЖ ВИНИТИ 34 (BI48) 95.09-04Т2.152

Автор(ы) : Klocking H.-P.
Заглавие : Acute t-PA releasing effect of supersulphated low molecular weight heparins
Источник статьи : Fibrinolysis. - 1994. - Vol. 8, Suppl. n 1. - С. 75-77
Аннотация: Different supersulphated low molecular weight heparins (SSLMWH), isolated after controlled depolymerisation and contemporary sulphatation of pig mucosal unfractionated heparin (Italian Patent 22504 A/89), were tested for their in vitro and in vivo t-PA releasing activity. The different SSH preparations developed profibrinolytic activity on the basis of tissue-type plasminogen activator (t-PA) release during perfusion of isolated pig ear and after i. v.-application in rats. The acute t-PA release induced by SSH 11, 13 and 14 was in a higher range in the isolated perfused pig ear model than that induced by unfractionated heparin at a concentration of 50 mg/ml perfusion solution. The highest acute increase of t-PA was caused by SSH 14 with 200%. SSH 14 was dose-dependently tested for acute t-PA release in rats after intravenous administration of 1.0, 2.5, 5.0 and 10.0 mg SSH/kg body weight. The maximum net increase of t-PA release was reached 1 to 5 min after i. v. application of SSH 14. After the administration of 5 or 10 mg/kg, resp., SSH 14 produced an increase in maximum t-PA release between 7 and 8 I. U./ml plasma. The t-PA releasing effect of SSLMWH might contribute to the antithrombotic effect of SSH 14. Библ. 10
ГРНТИ : 34.45.21
Предметные рубрики: ГЕПАРИНЫ НИЗКОМОЛЕКУЛЯРНЫЕ
СУПЕРСУЛЬФАТИРОВАННЫЕ
ТКАНЕВОЙ АКТИВАТОР ПЛАЗМИНОГЕНА
ВЫСВОБОЖДЕНИЕ
КРЫСЫ
СВИНЬИ
ФИБРИНОЛИЗ
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