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РЖ ВИНИТИ 34 (BI39) 96.04-04К1.722

Автор(ы) : Ginsberg Jeffrey S., Demers, Christine, Brill-Edwards, Patrick, Bona, Robert, Johnston, Marilyn, Wong, Albert, Denburg Judah A.
Заглавие : Acquired free protein S deficiency is associated with antiphospholipid antibodies and increased thrombin generation in patients with systemic lupus erythematosus
Источник статьи : Amer. J. Med. - 1995. - Vol. 98, N 4. - С. 379-388
Аннотация: In order to determine whether there is a relationship between acquired free protein S deficiency and increased thrombin generation, were performed a study of patients with systemic lupus erythematosus (SLE). Plasma samples were assayed for free protein S and were correlated to levels of prothrombin fragments (F1 + 2); an elevated level of F1 + 2 was used as a surrogate marker for a prothrombotic state. Assays for anticardiolipin antibodies (ACA) and lupus anticoagulant (LA) were performed on two separate blood samples taken at least 3 months apart in order to detect the presence of antiphospholipid antibodies. Of the 36 subjects, 9 had reduced free protein S levels compared to 0 of 21 controls (P = 0.01) and the mean free protein S level was significantly lower in the SLE population than in controls. Of the 24 subjects with antiphospholipid antibodies, 9 had reduced free protein S levels, compared to 0 of 12 subjects without antiphospholipid antibodies. The mean F1 + 2 level was significantly higher in study subjects with reduced free protein S levels than in those with normal free protein S levels. This study confirms an association between antiphospholipid antibodies and reduced free protein S levels and demonstrates that patients with SLE and acquired free protein S deficiency generate more thrombin than patients with SLE and normal free protein S levels. Канада, Dep. Med., McMaster Univ. Hamilton, Ont. Библ. 24
ГРНТИ : 34.43.57
Предметные рубрики: СИСТЕМНАЯ КРАСНАЯ ВОЛЧАНКА
СНИЖЕНИЕ УРОВНЯ БЕЛКА S
АНТИФОСФОЛИПИДНЫЕ АНТИТЕЛА
СИНТЕЗ ТРОМБИНА
ЧЕЛОВЕК
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