Поисковый запрос: (<.>S=ОБРАТНАЯ ТРАНСКРИПТАЗА ВИЧ-1<.>) |
Общее количество найденных документов : 28
Показаны документы с 1 по 20
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1.
| Тарасова О.А. ВЗАИМОСВЯЗИ "СТРУКТУРА-АКТИВНОСТЬ" ДЛЯ ИНГИБИТОРОВ ОБРАТНОЙ ТРАНСКРИПТАЗЫ ВИЧ-1: КАК ПОВЫСИТЬ ТОЧНОСТЬ И ПРЕДСКАЗАТЕЛЬНУЮ СПОСОБНОСТЬ ПОЛУЧАЕМЫХ МОДЕЛЕЙ? // ВИЧ-инфекция и иммуносупрессии, 2016. Т. 8, N 3.-С.80-84
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| Дьякова Л.Н. Синтез и исследование свойств глицеролипидных производных нуклеозидных ингибиторов обратной транскриптазы ВИЧ для повышения их биодоступности. - 2013
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| Aptamer beacons for visualization of endogenous protein HIV-1 reverse transcriptase in living cells // Biosens. and Bioelectron., 2011. Vol. 28, N 1.-С.270-276
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| Aptamer beacons for visualization of endogenous protein HIV-1 reverse transcriptase in living cells // Biosens. and Bioelectron., 2011. Vol. 28, N 1.-С.270-276
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| Inhibition of HIV-1 by octadecyloxyethyl esters of (S)-[3-hydroxy-2-(phosphonomethoxy)propyl]nucleosides and evaluation of their mechanism of action // Antimicrob. Agents and Chemother., 2011. Vol. 55, N 11.-С.5063-5072
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| Al-Soud Y.A. Synthesis, structure, and in vitro anti-HIV activity of new pyrazole, 1,2,4-thiadiazole, and 1,2,4-triazole derivatives // Phosph., Sulfur, and Silicon and Relat. Elem., 2008. Vol. 183, N 10.-С.2621-2636
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| Reduced dNTP binding affinity of 3TC-resistant M184I HIV-1 reverse transcriptase variants responsible for viral infection failure in macrophage // J. Biol. Chem., 2008. Vol. 283, N 14.-С.9206-9216
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| Slide into action: Dynamic shuttling of HIV reverse transcriptase on nucleic acid substrates // Science, 2008. Vol. 322, N 5904.-С.1092-1097
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| HIV-1 nucleocapsid traps reverse transcriptase on nucleic acid substrates // Biochemistry, 2008. Vol. 47, N 46.-С.12230-12240
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| Synthesis and anti-HIV-1 activity evaluation of 5-alkyl-2-alkylthio-6-(arylcarbonyl or 'альфа'-cyanoarylmethyl)-3,4-dihydropyrimidin-4(3H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors // J. Med. Chem., 2007. Vol. 50, N 8.-С.1778-1786
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11.
| Investigating the "steric gate" of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by targeted insertion of unnatural amino acids // Biochemistry, 2007. Vol. 46, N 8.-С.2118-2126
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| Synthesis, biological activity, and crystal structure of potent nonnucleoside inhibitors of HIV-1 reverse transcriptase that retain activity against mutant forms of the enzyme // J. Med. Chem., 2007. Vol. 50, N 17.-С.4003-4015
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13.
| Structure-activity relationships of [2',5'-bis-O-(tert-butyldimethylsilyl)-'бета'-D-ribofuranosyl]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine derivatives as inhibitors of HIV-1 reverse transcriptase dimerization // J. Med. Chem., 2006. Vol. 49, N 16.-С.4834-4841
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14.
| Geitmann Biosensor-based kinetic characterization of the interaction between HIV-1 reverse transcriptase and non-nucleoside inhibitors // J. Med. Chem., 2006. Vol. 49, N 8.-С.2367-2374
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| Geitmann Biosensor-based kinetic characterization of the interaction between HIV-1 reverse transcriptase and non-nucleoside inhibitors // J. Med. Chem., 2006. Vol. 49, N 8.-С.2367-2374
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| Geitmann Interaction kinetic characterization of HIV-1 reverse transcriptase non-nucleoside inhibitor resistance // J. Med. Chem., 2006. Vol. 49, N 8.-С.2375-2387
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| Kinetic evidence for interaction of human immunodeficiency virus type 1 reverse transcriptase with the 3'-OH of the incoming dTTP substrate // Biochemistry, 2005. Vol. 44, N 31.-С.10635-10643
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| Lanciault Single unpaired nucleotides facilitate HIV-1 reverse transcriptase displacement synthesis through duplex RNA // J. Biol. Chem., 2004. Vol. 279, N 31.-С.32252-32261
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| Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant reverse transcriptases resistant to other nonnucleoside inhibitors // Proc. Nat. Acad. Sci. USA, 2004. Vol. 101, N 29.-С.10548-10553
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20.
| Mutations E44D and V118I in the reverse transcriptase of HIV-1 play distinct mechanistic roles in dual resistance to AZT and 3TC // J. Biol. Chem., 2003. Vol. 278, N 36.-С.34403-34410
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