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библиографическое описание	краткий	полный

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Вид документа : Статья из журнала

РЖ ВИНИТИ 76 (BI29) 95.08-04Н1.026

Автор(ы) : Yamamoto, Masuji, Yoshida, Mitsunori, Ono, Koji, Fujita, Tsuyoshi, Ohtani-Fujita, Naoko, Sakai, Toshiyuki, Nikaido, Toshio
Заглавие : Effect of tumor suppressors on cell cycle-regulatory genes: RB suppresses p34{c}{d}{c}{2} expression and normal p53 suppresses cyclin A expression
Источник статьи : Exp. Cell Res. - 1994. - Vol. 210, N 1. - С. 94-101
Аннотация: We show that expression of the p34{c}{d}{c}{2} and cyclin A genes is induced by interleukin-2 in normal human T cells and present evidence to support the idea that these genes are deregulated in leukemic T cells. Our DNA sequencing data indicate that the promoter region of the p34{c}{d}{c}{2} gene contains putative E2F-like binding sites which are recognized by Rb and binding sites for c-myb, Sp1, and ATF, and that the promoter region of the cyclin A gene contains binding sites for p53, Sp1, and ATF. In this study we focus on the effect of p53 and Rb on these cell cycle-regulatory genes. Cotransfection of Y79 human retinoblastoma cells with a p34{c}{d}{c}{2} promoter-luciferase expression vector and a plasmid expressing the retinoblastoma gene (RB) indicated that RB suppresses p34{c}{d}{c}{2} expression. Cotransfection of В104 rat neuroblastoma cells with a cyclin A promoter-luciferase expression vector and a plasmid expressing the normal or mutant p53 indicated that only the normal p53 suppresses cyclin A expression. In normal T cells, PHA stimulation reduces the amount of complexes in the p34{c}{d}{c}{2} promoter between the E2F-like binding site and the RB gene product. These complexes were not detected in leukemic T cells. Our data support the idea that tumor suppressors modulate the expression of cell cycle-regulatory genes: RB regulates p34{c}{d}{c}{2} expression and p53 regulates cyclin A expression. США, Wistar Inst. Anat. and Biol., Philadelphia, PA 19 104. Библ. 48.
ГРНТИ : 76.29.49
Предметные рубрики: ГЕНЫ-СУПРЕССОРЫ ОПУХОЛИ
ГЕН РЕТИНОБЛАСТОМЫ
ГЕН Р53
БЕЛОК P34{C}{D}{C}{2}
ЦИКЛИН А
НЕЙРОБЛАСТОМА
ЛИНИЯ В104
КРЫСЫ
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