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РЖ ВИНИТИ 34 (BI39) 95.12-04К1.419

Автор(ы) : Seitz, Michael, Loetscher, Pius, Dewald, Beatrice, Towbin, Harry, Gallati, Harald, Baggiolini, Marco
Заглавие : Interleukin-10 differentially regulates cytokine inhibitor and chemokine release from blood mononuclear cells and fibroblasts
Источник статьи : Eur. J. Immunol. - 1995. - Vol. 25, N 4. - С. 1129-1132
Аннотация: In this study we have examined the effects of interleukin-10 (IL-10) on blood mononuclear cells (MNC) and on skin as well as on synovial fibroblasts. In unstimulated MNC, we found that IL-10 is a potent stimulator of interleukin-1 receptor antagonist (IL-1ra) and monocyte chemoattractant protein-1 (MCP-1) production and an inhibitor of IL-8 release. In cells exposed to IL-1'бета', it also moderately stimulated IL-1ra production and release of soluble tumor necrosis factor receptor p75 (sTNF-R p75) and inhibited IL-8 and MCP-1 production. In addition, we have evidence that the biological effects of IL-10 are not restricted to hematopoietic cells. IL-10 stimulated sTNF-R p55 dose-dependently and inhibited MCP-1 release from IL-1'бета'-activated fibroblasts, whereas IL-8 production was not affected. Taken together, these findings identify novel biological actions of IL-10 on blood mononuclear and connective tissue cells which support its regulatory functions as a suppressor of inflammatory processes. Швейцария, Univ. Hosp., Inselspital, Bern. Библ. 38
ГРНТИ : 34.43.37
Предметные рубрики: ИНТЕРЛЕЙКИН 10
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МОНОНУКЛЕАРНЫЕ КЛЕТКИ
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ИНГИБИТОР ЦИТОКИНОВ
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