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Вид документа : Статья из журнала

РЖ ВИНИТИ 76 (BI28) 96.02-04Н3.37

Автор(ы) : Otsuji, Eigo, Yamaguchi, Toshiharu, Yata, Yoshihiro, Nishi, Hiroshi, Okamoto, Kazuma, Taniguchi, Katsunori, Kato, Makoto, Kotani, Tatsuya, Yamaoka, Nobuki, Kitamura, Kazuya, Takahashi, Toshio
Заглавие : Antitumor effect of neocarzinostatin conjugated to human/mouse chimeric Fab fragments of the monoclonal antibody A7 on human pancreatic carcinoma
Источник статьи : J. Surg. Oncol. - 1994. - Vol. 57, N 4. - С. 230-234
Аннотация: The anticancer agent neocarzinostatin (NCS) was bound covalently to human/mouse chimeric Fab fragments of the monoclonal antibody A7 to form the conjugate chA7Fab-NCS. The antitumor effect of chA7Fab-NCS was tested by measuring the inhibition of {3}H-thymidine incorporation into human pancreatic carcinoma cells. The chA7Fab-NCS was approxumately 2.3 times as effective as free NCS against human pancreatic carcinoma cells which reacted with the monoclonal antibody A7. The ayntitumor activity of chA7Fab-NCS was inhibited by excess chA7Fab. ChA7Fab-NCS had an antitumor effect equivalent to free NCS on human pancreatic carcinoma cells which did not react with the monoclonal antibody A7. ChA7Fab-NCS appears to be a potentially useful conjugate for immunotargeting chemotherapy against pancreatic carcinoma. Библ. 24
ГРНТИ : 76.29.49
Предметные рубрики: КУЛЬТУРА КЛЕТОК
РАК ПОДЖЕЛУДОЧНОЙ ЖЕЛЕЗЫ
ХИМИОТЕРАПИЯ
ИММУНОНАПРАВЛЕННАЯ
МОНОКЛОНАЛЬНЫЕ АНТИТЕЛА A7
КОНЪЮГАТЫ
НЕОКАРЦИНОСТАТИН
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Вид документа : Статья из журнала

РЖ ВИНИТИ 34 (BI39) 96.02-04К1.471

Автор(ы) : Otsuji, Eigo, Yamaguchi, Toshiharu, Yata, Yoshihiro, Nishi, Hiroshi, Okamoto, Kazuma, Taniguchi, Katsunori, Kato, Makoto, Kotani, Tatsuya, Yamaoka, Nobuki, Kitamura, Kazuya, Takahashi, Toshio
Заглавие : Antitumor effect of neocarzinostatin conjugated to human/mouse chimeric Fab fragments of the monoclonal antibody A7 on human pancreatic carcinoma
Источник статьи : J. Surg. Oncol. - 1994. - Vol. 57, N 4. - С. 230-234
Аннотация: The anticancer agent neocarzinostatin (NCS) was bound covalently to human/mouse chimeric Fab fragments of the monoclonal antibody A7 to form the conjugate chA7Fab-NCS. The antitumor effect of chA7Fab-NCS was tested by measuring the inhibition of {3}H-thymidine incorporation into human pancreatic carcinoma cells. The chA7Fab-NCS was approxumately 2.3 times as effective as free NCS against human pancreatic carcinoma cells which reacted with the monoclonal antibody A7. The ayntitumor activity of chA7Fab-NCS was inhibited by excess chA7Fab. ChA7Fab-NCS had an antitumor effect equivalent to free NCS on human pancreatic carcinoma cells which did not react with the monoclonal antibody A7. ChA7Fab-NCS appears to be a potentially useful conjugate for immunotargeting chemotherapy against pancreatic carcinoma. Библ. 24
ГРНТИ : 34.43.17
Предметные рубрики: КУЛЬТУРА КЛЕТОК
РАК ПОДЖЕЛУДОЧНОЙ ЖЕЛЕЗЫ
ХИМИОТЕРАПИЯ
ИММУНОНАПРАВЛЕННАЯ
МОНОКЛОНАЛЬНЫЕ АНТИТЕЛА A7
КОНЪЮГАТЫ
НЕОКАРЦИНОСТАТИН
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