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Вид документа : Статья из журнала

РЖ ВИНИТИ 34 (BI14) 95.10-04Б4.87

Автор(ы) : Laszik, Zoltan, Nadasdy, Tibor, Johnson Loranine D., Lerner Megan R., Brackett, Daniel, Silva Fred G.
Заглавие : Renal interleukin-1 expression during endotoxemia and gram-negative septicemia in conscious rats
Источник статьи : Circ. Shock. - 1994. - Vol. 43, N 4. - С. 115-121
Аннотация: Endotoxin-induced cytokines such as interleukin-1 (IL-1) and tumor necrosis factor (TNF) are thought to contribute to the proinflammatory effects of endotoxin in gram-negative infections. Using a conscious rat model of sepsis, induced by intravenous challenge with LD[95] doses of endotoxin (n=24) or live Escherichia coli (E. coli) (n-24), we examined frozen sections of kidney at various intervals for evidence of IL-1 'альфа' and TNF 'альфа' expression. A transient glomerular endothelial IL-1 'альфа' expression was demonstrated at 30 and 90 min after initiation of the sepsis in both endotoxin and E. coli-treated animals using immunohistochemistry. The endothelial IL-1 'альфа' expression as determined by immunohistochemistry occurred at the same time as IL-1 'альфа' mRNA expression, as determined by Northern blot analysis. The glomerular endothelial IL-1 'альфа' expression coincided with a slight but significant increase in the number of the glomerular polymorphonuclear leukocytes as identified by naphthol AS-D chloroacetate esterase enzyme histochemical reaction. Glomerular endothelial IL-1 'альфа' expression was virtually absent by 180 and 360 min. No TNF 'альфа' expression was detected in the renal tissues at any time interval. Neither alpha-naphthyl acetate exterase-positive nor acid phosphatase-positive monocytes/macrophages were identified in the glomeruli. Our findings provide direct in vivo evidence that the IL-1 'альфа' gene product is expressed locally in the kidney by glomerular endothelial cells in this septic rat model. США, Dep. Pathol., Univ. Oklahoma Hlth Sci. Ctr., Oklahoma City. Библ. 43
ГРНТИ : 34.27.29
Предметные рубрики: ИНТЕРЛЕЙКИН 1
ЭКСПРЕССИЯ
КЛЕТКИ ПОЧКИ
ЭНДОТОКСЕМИЯ
СЕПТИЦЕМИЯ
ГРАМ-МОТРИЦАТЕЛЬНЫЕ БАКТЕРИИ
КРЫСЫ
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Вид документа : Статья из журнала

РЖ ВИНИТИ 34 (BI39) 95.09-04К1.284

Автор(ы) : Laszik, Zoltan, Nadasdy, Tibor, Johnson Loranine D., Lerner Megan R., Brackett, Daniel, Silva Fred G.
Заглавие : Renal interleukin-1 expression during endotoxemia and gram-negative septicemia in conscious rats
Источник статьи : Circ. Shock. - 1994. - Vol. 43, N 4. - С. 115-121
Аннотация: Endotoxin-induced cytokines such as interleukin-1 (IL-1) and tumor necrosis factor (TNF) are thought to contribute to the proinflammatory effects of endotoxin in gram-negative infections. Using a conscious rat model of sepsis, induced by intravenous challenge with LD[95] doses of endotoxin (n=24) or live Escherichia coli (E. coli) (n-24), we examined frozen sections of kidney at various intervals for evidence of IL-1 'альфа' and TNF 'альфа' expression. A transient glomerular endothelial IL-1 'альфа' expression was demonstrated at 30 and 90 min after initiation of the sepsis in both endotoxin and E. coli-treated animals using immunohistochemistry. The endothelial IL-1 'альфа' expression as determined by immunohistochemistry occurred at the same time as IL-1 'альфа' mRNA expression, as determined by Northern blot analysis. The glomerular endothelial IL-1 'альфа' expression coincided with a slight but significant increase in the number of the glomerular polymorphonuclear leukocytes as identified by naphthol AS-D chloroacetate esterase enzyme histochemical reaction. Glomerular endothelial IL-1 'альфа' expression was virtually absent by 180 and 360 min. No TNF 'альфа' expression was detected in the renal tissues at any time interval. Neither alpha-naphthyl acetate exterase-positive nor acid phosphatase-positive monocytes/macrophages were identified in the glomeruli. Our findings provide direct in vivo evidence that the IL-1 'альфа' gene product is expressed locally in the kidney by glomerular endothelial cells in this septic rat model. США, Dep. Pathol., Univ. Oklahoma Hlth Sci. Ctr., Oklahoma City. Библ. 43
ГРНТИ : 34.43.37
Предметные рубрики: ИНТЕРЛЕЙКИН 1
ЭКСПРЕССИЯ
КЛЕТКИ ПОЧКИ
ЭНДОТОКСЕМИЯ
СЕПТИЦЕМИЯ
ГРАМ-МОТРИЦАТЕЛЬНЫЕ БАКТЕРИИ
КРЫСЫ
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