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РЖ ВИНИТИ 34 (BI23) 96.05-04М2.261

Автор(ы) : Zhang, Jianyi, Duncker Dirk J., Xu, Ya, Zhang, Yi, Path, Greg, Merkle, Hellmut, Hendrich, Kristy, From Arthur H.L., Bache Robert J., Ugurbil, Kamil
Заглавие : Transmural bioenergetic responses of normal myocardium to high workstates
Источник статьи : Amer. J. Physiol. - 1995. - Vol. 268, N 5. - С. 1891-1905
Аннотация: The response of myocardial highenergy and inorganic phosphates (HEP and P[i.] respectively) and associated changes in myocardial blood flow, lactate uptake, and O[2] consumption (MVO[2]) rates were examined in an open-chest canine model during progressively increasing workloads achieved by catecholamine infusion. HEP and P[i] levels (measured with transmurally localized {31}P-nuclear magnetic resonance spectroscopy) were unaffected by moderate increases in the level of energy expenditure but were significantly altered by high workloads, especially in the subepicardium. The MVO[2] and HEP data from three different protocols that utilized pharmacological augmentation of blood flow demonstrated that the maximal rate of myocardial energy production during inotropic stimulation was dictated by perfusion limitation. This limitation was more severe in the subepicardial layer at the high workloads despite equiavalent or even higher increases in blood flow to this layer, reflecting a preferential enhancement of demand in the outer layer by catecholamines. Библ. 63
ГРНТИ : 34.39.29
Предметные рубрики: СЕРДЦЕ
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