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Вид документа : Статья из журнала

РЖ ВИНИТИ 76 (BI29) 03.08-04Н1.214

Автор(ы) : Mantaka P., Siedel C., Schrama D., Kampgen E., Brocker E.-B., Becker J.C.
Заглавие : Detection of micrometastases in the sentinel lymph nodes (SLN) of patients with primary malignant melanoma : Докл. [Joint Meeting of the European Association of Dermato-Oncology (EADO) and 11. Jahrestagung Arbeitsgemeinschaft Dermatologische Onkologie (ADO), Vienna, Sept. 27-29, 2001]
Источник статьи : H+G. - 2001. - Vol. 76, N 9. - С. 530
ГРНТИ : 76.29.49
Предметные рубрики: МЕЛАНОМА
МЕТАСТАЗЫ
ДИАГНОСТИКА
АНТИГЕН, АССОЦИИРОВАННЫЙ С МЕЛАНОМОЙ
ЧЕЛОВЕК
Дата ввода:

Вид документа : Статья из журнала

РЖ ВИНИТИ 34 (BI39) 89.12-04К1.720

Автор(ы) : Matzku, Siegfried, Kirchgessner, Henning, Schmid, Udo, Temponi, Massimo, Ferrone, Soldano
Заглавие : Melanoma targeting with a cocktail of monoclonal antibodies to distinct determinants of the human HMW-MAA
Источник статьи : J. Nucl. Med. - 1989. - Vol. 30, N 3. - С. 390-397
Аннотация: Кл линии меланомы Colo 38 и MeWo связывали мАТ 149.53, 225.28 и 763.74, к-рые распознают различ. детерминанты HMW-MAA. При использовании метода ингибиции связывания АТ установлено, что все эти мАТ не препятствуют друг другу при связывании с АГ. При культивировании Кл с радиоактивномеченными АТ показано, что воздействие комбинации АТ приводит к 2-3-кратному возрастанию связанной радиоактивности только в том случае, если АТ используются в насыщающей конц-ии. Кл меланомы (5 * 10{6}) ввели п/к nude мышам BALB/с. Когда диам. Оп достиг 10-15 мышам сышам ввели {1}{2}{5}I-мАТ по отдельности или в виде коктейля. В этом случае не наблюдали увеличения связавшейся с Оп радиоактивностью. Различия в опытах in vitro и in vivo могут объясняться особенностями экспрессии АТ в обоих случаях, характером распределения мАТ в Оп. Несмотря на то, что введение коктейля мАТ не повысило чувствительности иммуносцинтиграфии у мышей, это не исключает дополнительной проверки в клинич. условиях. Библ. 32. S. Matzku, PhD, DKFZ, P.B., 101 949, D-6900 Heidelberg. DB.
ГРНТИ : 34.43.33
Предметные рубрики: АНТИТЕЛА МОНОКЛОНАЛЬНЫЕ
АНТИГЕН, АССОЦИИРОВАННЫЙ С МЕЛАНОМОЙ
ИДЕНТИФИКАЦИЯ
Дата ввода:

Вид документа : Статья из журнала

РЖ ВИНИТИ 34 (BI39) 97.08-04К1.347

Автор(ы) : Kostadinov D.A.
Заглавие : Modulation of melanoma-associated antigen expression and shedding induced by mitomycin C in vitro : [Докл.] на Онкологич. дни, София, 1995
Источник статьи : Онкология. - 1995. - Vol. 32, N 3-4. - С. 20
Аннотация: The importance of chemotherapeutic agents for the treatment of human cancer is well known but their mechanism of action is still matter of debate. In general the antitumor effect of these agents is due to their cytotoxic action on the tumor cells by affecting DNA and/or protein synthesis. Many cancer chemotherapeutic agents, including mitomycin C (MMC), have also the capacity to immunopotentiate. They can augment both cellular and humoral immune responses to new antigens but also augment concomitant antitumor immunity in animal models and in human. This effect may be due to breaching natural and acquired tolerance to tumor antigens and/or to overexpression of these antigens in addition to the selective effects of the agents on immunoregulatory mechanisms. In this presentation it was reported the findings on the antigenic expression of human melanoma cell lines, SK MEL-1 and SK MEL-5, under influence of MMC in vitro. The study revealed some differences in the binding capacity for two specific monoclonal antibodies between the two cell lines, at treating with MMC. Decreased expression of NOC-1 epitope and increased of NOC-2 one following MMC treatment of SK MEL-1 cells in contrast to unchanged expression of both epitopes in SK MEL-5 cells were seen after treatment for up to 48 hrs at 37'ГРАДУС'C with MMC at 1 'мю'g/ml. When cells of the latter line were treated with lower doses (0.01-0.1) increased expression of both epitopes were found. Increased shedding of epitope-bearing molecules was also detected but only where high dose of MMC was used, as high as 100 'мю'g/ml. Taken together the results showed that the effects of chemotherapeutic agents must in general be defined for each tumor to provide optimum benefits for cancer patients in antibody-guided therapy with monoclonal antibodies
ГРНТИ : 34.43.45
Предметные рубрики: МЕЛАНОМА
АНТИГЕНЫ
АНТИГЕН, АССОЦИИРОВАННЫЙ С МЕЛАНОМОЙ
ЭКСПРЕССИЯ
ПРОТИВООПУХОЛЕВЫЕ СРЕДСТВА
МИТОМИЦИН С
IN VITRO
Дата ввода:

Вид документа : Статья из журнала

РЖ ВИНИТИ 76 (BI28) 97.07-04Н3.89

Автор(ы) : Kostadinov D.A.
Заглавие : Modulation of melanoma-associated antigen expression and shedding induced by mitomycin C in vitro : [Докл.] на Онкологич. дни, София, 1995
Источник статьи : Онкология. - 1995. - Vol. 32, N 3-4. - С. 20
Аннотация: The importance of chemotherapeutic agents for the treatment of human cancer is well known but their mechanism of action is still matter of debate. In general the antitumor effect of these agents is due to their cytotoxic action on the tumor cells by affecting DNA and/or protein synthesis. Many cancer chemotherapeutic agents, including mitomycin C (MMC), have also the capacity to immunopotentiate. They can augment both cellular and humoral immune responses to new antigens but also augment concomitant antitumor immunity in animal models and in human. This effect may be due to breaching natural and acquired tolerance to tumor antigens and/or to overexpression of these antigens in addition to the selective effects of the agents on immunoregulatory mechanisms. In this presentation it was reported the findings on the antigenic expression of human melanoma cell lines, SK MEL-1 and SK MEL-5, under influence of MMC in vitro. The study revealed some differences in the binding capacity for two specific monoclonal antibodies between the two cell lines, at treating with MMC. Decreased expression of NOC-1 epitope and increased of NOC-2 one following MMC treatment of SK MEL-1 cells in contrast to unchanged expression of both epitopes in SK MEL-5 cells were seen after treatment for up to 48 hrs at 37'ГРАДУС'C with MMC at 1 'мю'g/ml. When cells of the latter line were treated with lower doses (0.01-0.1) increased expression of both epitopes were found. Increased shedding of epitope-bearing molecules was also detected but only where high dose of MMC was used, as high as 100 'мю'g/ml. Taken together the results showed that the effects of chemotherapeutic agents must in general be defined for each tumor to provide optimum benefits for cancer patients in antibody-guided therapy with monoclonal antibodies
ГРНТИ : 76.29.49
Предметные рубрики: МЕЛАНОМА
АНТИГЕНЫ
АНТИГЕН, АССОЦИИРОВАННЫЙ С МЕЛАНОМОЙ
ЭКСПРЕССИЯ
ПРОТИВООПУХОЛЕВЫЕ СРЕДСТВА
МИТОМИЦИН С
IN VITRO
Дата ввода:

Вид документа : Статья из журнала

РЖ ВИНИТИ 76 (BI29) 97.07-04Н1.371

Автор(ы) : Kostadinov D.A.
Заглавие : Modulation of melanoma-associated antigen expression and shedding induced by mitomycin C in vitro : [Докл.] на Онкологич. дни, София, 1995
Источник статьи : Онкология. - 1995. - Vol. 32, N 3-4. - С. 20
Аннотация: The importance of chemotherapeutic agents for the treatment of human cancer is well known but their mechanism of action is still matter of debate. In general the antitumor effect of these agents is due to their cytotoxic action on the tumor cells by affecting DNA and/or protein synthesis. Many cancer chemotherapeutic agents, including mitomycin C (MMC), have also the capacity to immunopotentiate. They can augment both cellular and humoral immune responses to new antigens but also augment concomitant antitumor immunity in animal models and in human. This effect may be due to breaching natural and acquired tolerance to tumor antigens and/or to overexpression of these antigens in addition to the selective effects of the agents on immunoregulatory mechanisms. In this presentation it was reported the findings on the antigenic expression of human melanoma cell lines, SK MEL-1 and SK MEL-5, under influence of MMC in vitro. The study revealed some differences in the binding capacity for two specific monoclonal antibodies between the two cell lines, at treating with MMC. Decreased expression of NOC-1 epitope and increased of NOC-2 one following MMC treatment of SK MEL-1 cells in contrast to unchanged expression of both epitopes in SK MEL-5 cells were seen after treatment for up to 48 hrs at 37'ГРАДУС'C with MMC at 1 'мю'g/ml. When cells of the latter line were treated with lower doses (0.01-0.1) increased expression of both epitopes were found. Increased shedding of epitope-bearing molecules was also detected but only where high dose of MMC was used, as high as 100 'мю'g/ml. Taken together the results showed that the effects of chemotherapeutic agents must in general be defined for each tumor to provide optimum benefits for cancer patients in antibody-guided therapy with monoclonal antibodies
ГРНТИ : 76.29.49
Предметные рубрики: МЕЛАНОМА
АНТИГЕНЫ
АНТИГЕН, АССОЦИИРОВАННЫЙ С МЕЛАНОМОЙ
ЭКСПРЕССИЯ
ПРОТИВООПУХОЛЕВЫЕ СРЕДСТВА
МИТОМИЦИН С
IN VITRO
Дата ввода:

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