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Вид документа : Статья из журнала

РЖ ВИНИТИ 34 (BI23) 96.03-04М2.638

Автор(ы) : Romppanen, Jarkko, Mononen, Ilkka
Заглавие : Age-related reference values for urinary excretion of sialic acid and deoxysalic acid: Application to diagnosis of storage disorders of free sialic acid
Источник статьи : Clin. Chem. - 1995. - Vol. 41, N 4. - С. 544-547
Аннотация: We have established by HPLC age-related reference intervals for sialic acid urinary excretion in 364 control individuals to assist in evaluating the clinical significance of the free sialic acid concentration in urine. In addition, an HPLC method for quantitative analysis of free deoxysialic acid was developed, and age-related reference intervals for excretion of this compound in urine were established. In patients with storage disorders of free sialic acid (n=11) the sialic acid excreation was increased 2- to 35-fold, compared with the mean value of the control subjects in the corresponding age group, and exceeded the interval in each case. The excretion of deoxysialic acid was within the reference interval in all of the patients, indicating that its metabolism was not affected in the disorders. The age-related reference values assist in evaluating the excretion of free sialic acid in the diagnosis of storage disorders of free sialic acid, especially in young children. Финляндия, Dep. Clin. Chem., Kuopio Univ. Hosp., FIN-70211 Kuopio. Библ. 20
ГРНТИ : 34.39.35
Предметные рубрики: МОЧА
ЭКСКРЕЦИЯ
СИАЛОВЫЕ К-ТЫ
ДИАГНОСТИЧЕСКОЕ ЗНАЧЕНИЕ
ВОЗРАСТ
ЧЕЛОВЕК
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Вид документа : Статья из журнала

РЖ ВИНИТИ 76 (BI29) 97.11-04Н1.383

Автор(ы) : Romppanen, Jarkko, Eskelinen, Matti, Tikanoja, Sari, Mononen, Ilkka
Заглавие : Total and lipid-bound serum sialic acid in benign and malignant breast disease
Источник статьи : Anticancer Res. - 1997. - Vol. 17, N 2 b. - С. 1249-1253
Аннотация: Elevation in the total sialic acid (TSA), TSA/total protein (TSA/TP) and lipid-bound sialic acid (LASA) concentration in serum occurs in breast cancer and it was studied the applicability of the assays in classification of undefined breast tumors. Sialic acid was determined by HPLC and the statistical evaluation included the receiver operating characteristic (ROC) and Youden's index analyses. In cancer patients, the serum LASA and TSA concentration was significantly higher (p0.05) than in patients with benign breast disease and all the markers were significantly higher (p0.0001) than in normal controls. All the markers had a low accuracy (AUCs0.75) in differentiating between breast cancer and benign breast disease and at the specificity level of 0.95 the corresponding sensitivities were 0.32 (TSA), 0.14 (TSA/TP) and 0.23 (LASA). The results indicate that both breast cancer and benign breast disease cause elevation of TSA, TSA/TP and LASA values in serum and do not provide reliable classification of undefined breast tumors. Библ. 24
ГРНТИ : 76.29.49
Предметные рубрики: РАК МОЛОЧНОЙ ЖЕЛЕЗЫ
ДИФФЕРЕНЦИАЛЬНАЯ ДИАГНОСТИКА
СИАЛОВЫЕ КИСЛОТЫ
СВЯЗАННЫЕ С ЛИПИДАМИ
ЧЕЛОВЕК
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