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РЖ ВИНИТИ 34 (BI39) 95.08-04К1.421

Автор(ы) : Kan, On, Baldwin Stephen A., Whetton Anthony D.
Заглавие : Apoptosis is regulated by rate of glucose transport in an interleukin 3 dependent cell line
Источник статьи : J. Exp. Med. - 1994. - Vol. 180&(!&), N 3. - С. 917-923
Аннотация: In the absence of a survival stimulus, the interleukin 3 (IL-3)-dependent IC.DP cell line undergoes a process termed programmed cell death of apoptosis. Survival can be induced by IL-3, which can also stimulate proliferation of IC.DP cells. IC.DP cells have been stably transfected with the p160{v-abl} protein tyrosine kinase, activation of the kinase at the permissive temperature permits cell survival in the absence of IL-3 by suppression of apoptosis, although the growth factor is still required for proliferation. Both IL-3 and activation of the v-ABL tyrosine kinase stimulated glucose transport, which may in part be due to a translocation of transporters to the cell surface. Inhibition of glucose uptake markedly increased the rate of apoptosis in these cells, an effect that could be reversed by the provision of alternative energy sources such as glutamine. Growth factor- or oncogene-mediated increases in glucose uptake may therefore represent an important regulator point in the suppression of apoptosis. Великобритания, Leukaemia Res. Fund Group, UMIST, Manchester
ГРНТИ : 34.43.35
Предметные рубрики: АПОПТОЗ
ЛИМФОИДНЫЕ КЛЕТКИ
КУЛЬТИВИРУЕМАЯ ЛИНИЯ IC.DP
СКОРОСТЬ ПЕРЕНОСА ГЛЮКОЗЫ
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