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РЖ ВИНИТИ 34 (BI23) 96.02-04М2.577

Автор(ы) : Hershman K.M., Taylor D.A., Fleming W.W.
Заглавие : Adaptive supersensitivity and the Na{+}/K{+} pump in the guinea pig vas deferens: Time course of the decline in the 'альфа'2 subunit
Источник статьи : Mol. Pharmacol. - 1995. - Vol. 47, N 4. - С. 726-729
Аннотация: Guinea pigs were treated with reserpine (1.0 mg/kg/day, intraperitoneally) for 2, 5, or 8 days. Tissues were homogenized and the concentration of the 'альфа'2 subunit was quantified by use of the selective antibody McB2, slot blot analysis, enhanced chemiluminescence, and densitometric analysis. As reported previously, the concentration of the 'альфа'2 protein was reduced 41% after 5 days of pretreatment. The reduction was maintained at 8 days (37%). However, there was no change from control after 2 days of pretreatment with reserpine. Thus, the time course of the decline in the 'альфа'2 subunit is similar to that of the appearance of supersensitivity, depolarization, and the declines in Na{+}/K{+}-ATPase and [{3}H]ouabain binding established earlier. Based upon results in the literature for several different tissues and species, membrane depolarization and decreases in Na{+}/K{+} pump sites may represent widely occurring adaptive mechanisms. Библ. 27
ГРНТИ : 34.39.29
Предметные рубрики: СЕМЯВЫНОСЯЩИЙ ПРОТОК
РЕЗЕРПИН
СВЕРХЧУВСТВИТЕЛЬНОСТЬ
НАТРИЙ-КАЛИЕВЫЙ НАСОС
БЕЛОК 'АЛЬФА'2
МОРСКИЕ СВИНКИ
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